VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene called rs2228570 (FokI polymorphism), is associated with a decrease in bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal on-and-off occupancy of the VDRE between the two components. It is also modulated by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells demonstrate that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is a repository of information and documents that are relevant to business, legal transactions or other processes. Access to the data, downloading, or printing are not permitted. It uses a central computer as well as an extranet which is a restricted-access Internet connection, allowing users to log on at set times.
VDRs are primarily used by investment banks and companies involved in mergers Going Here or acquisitions. They require to share information in a transparent manner with potential investors or buyers. Due diligence processes will also require a significant amount of information. Life science companies also use VDRs for everything from clinical trial data to HIPAA documentation for compliance.